一位住在阿巴拉契亚小镇的律师出身的传教士，被一位古怪的男子追捧，希望他能代表自己出庭。如今，这位前律师卷入了一桩与他小镇生活息息相关的案件，于是他同意帮助一名男子。

即将去世的母亲莎拉告诉她的大儿子德鲁，她最后的愿望是让他带着弟弟威尔去他们出生的地方。尽管家庭历史悲惨，但希望给未来带来了希望。

因出柜被爸妈赶出家门的杰克（科纳·东纳利 饰），与离家出走的汤姆（肖恩·奥蒙德 饰），这一对亡命鸳鸯的组合，刚刚成年，就要独立面对生活的压力。生活，将使他们何去何从……

影片根据1959年发生在密歇根州一家精神病院的真实故事改编：精神科医生米尔顿·罗克奇(理查·基尔饰)在3名认为自己是耶稣·基督的精神分裂症患者身上实施了一项充满争议的实验。朱莉安娜将饰演医生的妻子；而3位精神病患者将分别由“小恶魔”彼得·丁克拉奇、布莱德利·惠特福德和沃尔顿·戈金斯扮演。

音乐收藏家奥利·斯韦招募了他唯一的朋友，一个吵闹的俄罗斯流浪者，帮助他从自己家里的庄园里偷了一张78张唱片。

Hayley Udall tries to make ends meet for herself and her 14 year-old daughter while providing alimony for a horrible ex-husband. She wishes her problems with her ex could go away, and upon venting her frustrations one night, finds herself tangled up in a pact with two people (Melanie and Kevin) to "eliminate" each other's problems. It seemed innocent wishful thinking before, but as people end up dead-including Hayley's ex-husband-Hayley is trapped to fulfill the pact or risk taking the fall for murder. She tries to clear her name but the police (led by Detective Marks) is eyeing her for her ex-husband's death as well as others. Then Melanie abducts Hayley's daughter as leverage for Hayley to follow through and kill one last person. With Detective Marks trying to find the truth, Hayley must hurry to save her daughter and find a way to avoid murder.

故事围绕驻扎伊拉克的两名士兵展开，队友受伤，神秘狙击手的穷追不舍，矮墙铸成最后一道生命线。两人将何去何存？一场猫鼠游戏在所难免。